SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome

Hutchinson-Gilford progeria syndrome is L-LEUCINE POWDER a genetic disease where an aberrant form of Lamin A disrupts chromatin by interfering with lamina associated domains.Here, the authors present the SAMMY-seq, a method for genome-wide characterization of heterochromatin dynamics and detect early stage alterations of heterochromatin structure in Central Locking progeria primary fibroblasts, accompained by Polycomb dysfunctions.